2. Signaling Pathways
  3. PROTAC
  4. PROTAC Linkers

PROTAC Linkers

PROTAC Linkers

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PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.

The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.

PROTAC Linkers Isoform Specific Products:

PROTAC Linkers Isoform Comparison
Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-141251
    N-(Hydroxy-PEG3)-N-bis(PEG4-Boc) 2112734-70-8
    N-(Hydroxy-PEG3)-N-bis(PEG4-Boc) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-(Hydroxy-PEG3)-N-bis(PEG4-Boc)
  • HY-120845
    Tr-PEG5-OH 141282-24-8
    Tr-PEG5-OH is a non-cleavable 5 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Tr-PEG5-OH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Tr-PEG5-OH
  • HY-130586
    Mal-PEG3-PFP ester 1807534-78-6
    Mal-PEG3-PFP ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs.
    Mal-PEG3-PFP ester
  • HY-133061
    Fluorescein-thiourea-PEG6-acid 2055014-69-0
    Fluorescein-thiourea-PEG6-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Fluorescein-thiourea-PEG6-acid
  • HY-W096081
    Benzyl-PEG10-alcohol 908258-44-6
    Benzyl-PEG10-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Benzyl-PEG10-alcohol
  • HY-132068
    THP-PEG7-alcohol 873110-21-5
    THP-PEG7-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    THP-PEG7-alcohol
  • HY-140568
    N-(Hydroxy-PEG3)-N-Boc-PEG4-Boc
    N-(Hydroxy-PEG3)-N-Boc-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    N-(Hydroxy-PEG3)-N-Boc-PEG4-Boc
  • HY-163758
    COOH-C3-CONH-C7-COOH
    COOH-C3-COGN-C7-COOH is a PEG based linker for PROTAC. COOH-C3-COGN-C7-COOH can be used for synthesis of PROTAC Degrader ARM165 (HY-163677).
    COOH-C3-CONH-C7-COOH
  • HY-140482
    Acid-PEG6-C2-Boc 2093153-84-3
    Acid-PEG6-C2-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Acid-PEG6-C2-Boc
  • HY-133437
    BCN-PEG4-alkyne
    BCN-PEG4-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. BCN-PEG4-alkyne is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    BCN-PEG4-alkyne
  • HY-156700
    Lenalidomide-acetylene-Br 2619512-84-2
    Lenalidomide-acetylene-Br is a PROTAC Linker taht makes up HJM-561 (HY-156698). HJM-561 is a potent, selective, and orally active EGFR PROTAC to inhiibit Osimertinib (HY-15772)-resistant EGFR triple mutations.
    Lenalidomide-acetylene-Br
  • HY-140829
    m-PEG11-azide
    m-PEG11-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. m-PEG11-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    m-PEG11-azide
  • HY-140347
    APN-C3-NH-Boc 1539292-60-8
    APN-C3-NH-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. APN-C3-NH-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    APN-C3-NH-Boc
  • HY-140294
    DBCO-C2-PEG4-NH-Boc
    DBCO-C2-PEG4-NH-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-C2-PEG4-NH-Boc is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-C2-PEG4-NH-Boc
  • HY-138401
    Dimethylamine-PEG19
    Dimethylamine-PEG19 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    Dimethylamine-PEG19
  • HY-135935
    DBCO-NHCO-PEG2-CH2COOH
    DBCO-NHCO-PEG2-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. DBCO-NHCO-PEG2-CH2COOH is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
    DBCO-NHCO-PEG2-CH2COOH
  • HY-141064
    N-(azide-PEG3)-N'-(m-PEG4)-Benzothiazole Cy5 2107273-88-9
    N-(azide-PEG3)-N'-(m-PEG4)-Benzothiazole Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(azide-PEG3)-N'-(m-PEG4)-Benzothiazole Cy5 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    N-(azide-PEG3)-N'-(m-PEG4)-Benzothiazole Cy5
  • HY-140788
    Azide-PEG9-amido-C4-Boc
    Azide-PEG9-amido-C4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azide-PEG9-amido-C4-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    Azide-PEG9-amido-C4-Boc
  • HY-140024
    Propargyl-PEG4-CH2-acid 1872433-74-3
    Propargyl-PEG4-CH2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG4-CH2-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Propargyl-PEG4-CH2-acid
  • HY-140711
    HO-PEG-CH2COOH (MW 3400)
    HO-PEG-CH2COOH (MW 3400) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
    HO-PEG-CH2COOH (MW 3400)
PROTAC Linkers Isoform Comparison

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